expression of melanocortin-4 receptor and agouti-related peptide mrnas in arcuate nucleus during long term malnutrition of female ovariectomized rats

Authors

fatemeh sabet sarvestani infertility research center, shiraz university of medical sciences, shiraz, iran

amin tamadon infertility research center, shiraz university of medical sciences, shiraz, iran transgenic te.chnology research center, shiraz university of medical sciences, shiraz, iran

aida hematzadeh transgenic technology research center, shiraz university of medical sciences, shiraz, iran

maliheh jahanara transgenic technology research center, shiraz university of medical sciences, shiraz, iran

abstract

objective: melanocortin-4 receptor (mc4r) and agouti-related peptide (agrp) are involved in energy homeostasis in the rat. the aim of the present study was to evaluate the expression of mc4r and agrp mrnas in arcuate nucleus (arc) during long term malnutrition of female ovariectomized rats. materials and methods: ten female ovariectomized rats were divided into two equal groups (n=6) of normal and restricted diet groups. using real-time pcr, the relative expressions (compared to controls) of mc4r and agrp mrnas were compared between both diet groups. results: the relative expression of mc4r and agrp mrna in the arc of female ovariectomized rats during long term malnutrition was higher than those with normal diet (p<0.05). conclusion: changes in the relative expression level of mc4r and agrp mrnas during long term malnutrition of rat indicated a stimulatory role of mc4r and agrp in regulating energy balance in arc of rat hypothalamus.

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Journal title:
iranian journal of basic medical sciences

جلد ۱۸، شماره ۱، صفحات ۱۰۴-۱۰۷

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